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Processing of Cytosolic Antigens for Display by Class I MHC Molecules The main steps in antigen presentation by class I MHC molecules are the tagging of antigens in the cytosol or nucleus for proteolysis, proteolytic generation of peptide fragments of the antigen by a specialized cytosolic enzyme c…

Processing of Cytosolic Antigens for Display by Class I MHC Molecules The main steps in antigen presentation by class I MHC molecules are the tagging of antigens in the cytosol or nucleus for proteolysis, proteolytic generation of peptide fragments of the antigen by a specialized cytosolic enzyme complex called the proteasome, transport of peptides into the (ER), binding of peptides to newly synthesized class I molecules, and transport of peptide-MHC complexes to the cell surface