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Molecules encoded in the major histocompatibility complex (MHC) perform the function of displaying peptides derived from protein antigens. MHC genes are highly polymorphic. Their major products are class I and class II MHC molecules, which contain peptide-binding clefts, where the polymorphic resid…

Molecules encoded in the major histocompatibility complex (MHC) perform the function of displaying peptides derived from protein antigens. MHC genes are highly polymorphic. Their major products are class I and class II MHC molecules, which contain peptide-binding clefts, where the polymorphic residues are concentrated, and invariant regions, which bind the coreceptors CD8 and CD4, respectively.