Did you notice that Mark throws away his tissues and a bottle of lotion before Amber comes over for their study date in season 1. But when she breaks up with them, the tissues and lotion are instantly back. And when he goes to college, Mark is too busy with Amber to even have time for himself. But when they officially break up, the tissues make another appearance in his dorm room. Thankfully, they are not needed for much longer since Mark wastes no time getting together with Eve in season 3.