The peptides that are produced are transported by the transporter associated with antigen processing (TAP) into the endoplasmic reticulum (ER), where the peptides may be further trimmed. Newly synthesized class I MHC molecules are initially stabilized by chaperones and attached to TAP by a linker p…
The peptides that are produced are transported by the transporter associated with antigen processing (TAP) into the endoplasmic reticulum (ER), where the peptides may be further trimmed. Newly synthesized class I MHC molecules are initially stabilized by chaperones and attached to TAP by a linker protein called tapasin, so the MHC molecules are strategically located to receive peptides that are transported into the ER by TAP.