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What Happens If You Don’t Sleep for 72 Hours [0 HOURS – WAKING UP AFTER YOUR LAST SLEEP] You wake up feeling normal. Your body is rested. Your brain is sharp. Reaction time, memory, focus — all working perfectly. But this is the last time your body will feel balanced for a while. [12 HOURS WITHOUT SLEEP] You’ve been awake half a day longer than usual. Your brain starts to slow slightly. You feel more tired, less focused. Your reaction time drops — similar to having a small amount of alcohol in